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Regenerative medicine products, which are intended to repair or replace damaged cells or tissues in the body, include a range of therapeutic approaches such as cell- and gene-based therapies, engineered tissues, and non-biologic constructs. The current approach to characterizing the quality of a regenerative medicine product and the manufacturing process often involves measuring as many endpoints as possible, but this approach has proved to be inadequate and unsustainable. The Forum on Regenerative Medicine of the National Academies of Sciences, Engineering, and Medicine convened experts across disciplines for a 2-day virtual public workshop to explore systems thinking approaches and how they may be applied to support the identification of relevant quality attributes that can help in the optimization of manufacturing and streamline regulatory processes for regenerative medicine. A broad array of stakeholders, including data scientists, physical scientists, industry researchers, regulatory officials, clinicians, and patient representatives, discussed new advances in data acquisition, data analysis and theoretical frameworks, and how systems approaches can be applied to the development of regenerative medicine products that can address the unmet needs of patients. This publication summarizes the presentation and discussion of the workshop.
How can systems-thinking contribute to solving key challenges in Global Health? Global Health is an evolving field operating within a complex interaction of political, environmental, economic, and socio-cultural factors. Any work on the subject needs to reflect current developments and be supported by a collaborative, interdisciplinary approach that retains a focus on the underpinning determinants of health. This book reflects the importance of applying a systems-thinking approach to Global Health challenges: one that examines both the individual elements within the system as well as the interrelationships between them and wider contextual patterns. Bringing together a global and multidisciplinary team of experts, this volume outlines the core concepts of a systems-thinking approach and how they can be applied to current Global Health problems. It provides a comprehensive range of case studies, reflections, conceptual pieces, and methodological approaches. Readers are invited to engage with arguments and assumptions across global health interventions and to connect systems-thinking theory with lived experiences. Well-established topics such as infectious and non-communicable diseases, as well as lesser-discussed areas such as still birth, mental health, and war and conflict are united under a shared systems-thinking framework. Offering innovative perspectives on current health challenges, students, academics, practitioners, and policy makers will find this a significant resource to enhance their understanding and application of systems-thinking in Global Health.
This book utilizes a systems thinking perspective to propose a holistic framework of analysis and practice for the regional security community (“RSC”) arrangement in Africa. In responding to the challenge of improving effectiveness of response to peace and security threats, African states tend to rely on ad hoc mechanisms. However, this approach has been mired with a myriad of structural limitations. The holistic framework reconfigures the traditional “RSC” into a simplified tool kit of “resources”, making this text book ideal for students and advanced researchers in international relations, and all those concerned with regional security and strategic studies.
Sadallah Wannous (1941-1997), a leading Syrian playwright, was concerned in his political theater with preaching democracy and raising the awareness of the masses in order to have more involvement in the public arena. His drama was hurdled with censorship and he had to find indirect ways in his plays to instigate opposition. This article investigates whether the lack of freedom of expression curbs the creativity of the dramatist. My aim is to study and evaluate the dramatic techniques Wannous used in his attempt to circumvent censorship. This is mainly done through a critique of his plays in the light of my textual analysis, Wannous’s statements in his non dramatic writing and available literary criticism. Wannous’s polemical play An Evening for the fifth of June (1967-8) was banned after the first performance. Two later plays were chosen for this study; The King’s Elephant (1969) and The King is King (1977). In both plays, Wannous analyzed the nature of authoritarianism and the psyche of the repressed majority, and urged for dissent in far fetched plots that do not directly reflect the status quo. To do so, he made extensive use of fables, folk tales, allegory and symbolism. By exploring new theatrical modes, Wannous was able, not only to politicize the masses, but also to produce high quality art that is thought-provoking and entertaining at the same time. For the purpose of economy I limited my article to two plays. However The Adventure of the Slave Jaber’s Head (1970) is very pertinent to the main question herein and can be added later in a more extended book-length study.
Literature with A White Helmet explores issues of refugee writers, contemporary works of fiction and nonfiction on the refugee’s body and experience, the biopolitics of refugees, and disputes over the ethicality of representing refugees by writers and human rights activists. The book relies on a broad selection of texts by authors who, in one way or another, have experienced displacement, witnessed it, imagined it, or co-written about it.
This important book looks at the tumultuous recent events in the Arab region in the context of long-term historical pressure to build societies that will respond to Arab citizens’ longing for freedom and opportunity. Only through the painstaking process of constructing an Arab world defined by pluralism and tolerance can this dream be realized.
Marwan Muasher, former foreign minister of Jordan, asserts that all sides—the United States, Europe, Israel, and Arab governments alike—were deeply misguided in their thinking about Arab politics and society when the turmoil of the Arab Spring erupted. He explains the causes of the unrest, tracing them back to the first Arab Awakening, and warns of the forces today that threaten the success of the Second Arab Awakening. Hope rests with the new generation and its commitment to tolerance, diversity, the peaceful rotation of power, and inclusive economic growth, Muasher maintains. He calls on the West to rethink political Islam and the Arab Israeli conflict, and he underscores the importance of efforts to strengthen education and expand traditional definitions of Arab citizenship for the long-term process of democratic transition.
This book is premised on the notion that subnational undemocratic regimes (SURs) within countries not only differ among each other but that they maintain different relations with the federal government, which is why they are reproduced differently. The book argues that alternative pathways of SUR continuity result first and foremost from the capacity (or lack thereof) of democratic presidents to wield power over SURs and autocrats. If presidents have the (fiscal or partisan) resources to induce cooperation from subnational autocrats and can thus secure credible and routine political support, the former have strong incentives to invest in the continuity and stability of undemocratic provincial regimes and autocrats. Under these circumstances, SUR reproduction from above takes place. Conversely, if presidents fail to exert effective power and are prevented from disciplining subnational autocrats via fiscal or partisan means, they will implement policies to oppose and weaken SURs. This does not necessarily lead to SUR breakdown. Local variables, such as subnational autocrats’ capacity to ensure party elite unity and/or mass political support, shape autocrats’ ability to counterbalance presidential attempts at destabilization, and also allow autocrats to keep their regimes alive. Where this occurs, SUR self-reproduction takes place. This explanation of SUR continuity is tested in contemporary Argentina and Mexico using a multi-method approach. Both quantitative and qualitative methods, as well as cross-national and within-country comparisons, are employed to test pathways of SUR continuity in two of Latin America’s largest countries.
Certain regions of the world experience more conflict than others. Previous analyses have shown that a civil war in one country significantly increases the likelihood that neighboring states will experience conflict. This finding, however, still remains largely unexplained. We argue that population movements are an important mechanism by which conflict spreads across regions. Refugee flows are not only the consequence of political turmoil—the presence of refugees and displaced populations can also increase the risk of subsequent conflict in host and origin countries. Refugees expand rebel social networks and constitute a negative externality of civil war. Although the vast majority of refugees never directly engage in violence, refugee flows may facilitate the transnational spread of arms, combatants, and ideologies conducive to conflict; they alter the ethnic composition of the state; and they can exacerbate economic competition. We conduct an empirical analysis of the link between refugees and civil conflict since the mid-twentieth century, and we find that the presence of refugees from neighboring countries leads to an increased probability of violence, suggesting that refugees are one important source of conflict diffusion.
A History of the Modern Middle East examines the profound and often dramatic transformations of the region in the past two centuries, from the Ottoman and Egyptian reforms, through the challenge of Western imperialism, to the impact of US foreign policies. Built around a framework of political history, while also carefully integrating social, cultural, and economic developments, this expertly crafted account provides readers with the most comprehensive, balanced and penetrating analysis of the modern Middle East.