Systems Thinking inspired works; works explaining the systems thinking framework; listing of works that engage with or apply the systems thinking approach.
Regenerative medicine products, which are intended to repair or replace damaged cells or tissues in the body, include a range of therapeutic approaches such as cell- and gene-based therapies, engineered tissues, and non-biologic constructs. The current approach to characterizing the quality of a regenerative medicine product and the manufacturing process often involves measuring as many endpoints as possible, but this approach has proved to be inadequate and unsustainable. The Forum on Regenerative Medicine of the National Academies of Sciences, Engineering, and Medicine convened experts across disciplines for a 2-day virtual public workshop to explore systems thinking approaches and how they may be applied to support the identification of relevant quality attributes that can help in the optimization of manufacturing and streamline regulatory processes for regenerative medicine. A broad array of stakeholders, including data scientists, physical scientists, industry researchers, regulatory officials, clinicians, and patient representatives, discussed new advances in data acquisition, data analysis and theoretical frameworks, and how systems approaches can be applied to the development of regenerative medicine products that can address the unmet needs of patients. This publication summarizes the presentation and discussion of the workshop.
How can systems-thinking contribute to solving key challenges in Global Health? Global Health is an evolving field operating within a complex interaction of political, environmental, economic, and socio-cultural factors. Any work on the subject needs to reflect current developments and be supported by a collaborative, interdisciplinary approach that retains a focus on the underpinning determinants of health. This book reflects the importance of applying a systems-thinking approach to Global Health challenges: one that examines both the individual elements within the system as well as the interrelationships between them and wider contextual patterns. Bringing together a global and multidisciplinary team of experts, this volume outlines the core concepts of a systems-thinking approach and how they can be applied to current Global Health problems. It provides a comprehensive range of case studies, reflections, conceptual pieces, and methodological approaches. Readers are invited to engage with arguments and assumptions across global health interventions and to connect systems-thinking theory with lived experiences. Well-established topics such as infectious and non-communicable diseases, as well as lesser-discussed areas such as still birth, mental health, and war and conflict are united under a shared systems-thinking framework. Offering innovative perspectives on current health challenges, students, academics, practitioners, and policy makers will find this a significant resource to enhance their understanding and application of systems-thinking in Global Health.
This book utilizes a systems thinking perspective to propose a holistic framework of analysis and practice for the regional security community (“RSC”) arrangement in Africa. In responding to the challenge of improving effectiveness of response to peace and security threats, African states tend to rely on ad hoc mechanisms. However, this approach has been mired with a myriad of structural limitations. The holistic framework reconfigures the traditional “RSC” into a simplified tool kit of “resources”, making this text book ideal for students and advanced researchers in international relations, and all those concerned with regional security and strategic studies.