President Barack Obama won the 2008 US presidential race with promises to restore America’s lost image and status in the world, to lead the world again to achieve peace and dignity, and to start a “new beginning” with Muslims worldwide. This article examines Obama’s promised “new beginning” with Muslims in the Middle East and assesses his Middle East policy to determine whether his policy marks a break from the previous George W. Bush administration’s Mideast policy. First, it presents a comparative discussion on Bush’s and Obama’s Mideast policies and then turns to analyze a series of important issues that critically affects US-Mideast relations. It concludes that in the last five years (2009-2013) President Obama has, at best, achieved a mixed record –in some cases his approach has produced positive outcomes, in other cases, his policy is more a continuation of George W. Bush’s policy.