The Arab Uprisings and their transformational impact across MENA have generated immense debate about the future of the region’s countries during a period of reorganizational crisis in the international political economy. At this stage of the unfolding region-wide transition in the MENA, this paper performs a two-step theoreticopractical examination of the processes between and after the Uprisings. A discussion will ensue on the prospective changes these nations will face in terms of the potential trajectories of systemic change between the embedded path-dependencies of the established regimes and the patterns of change demanded by the subversive Islamic factions.